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25-Hydroxycholesterol

Chemical compound

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The CYP3A4 enzyme, a member of the cytochrome P450 family, can catalyze the oxidation of 25-hydroxycholesterol to 7α,25-dihydroxycholesterol, whereas 25-hydroxycholesterol can inhibit CYP4F2 mRNA expression, so that members of the cytochrome P450 family are also involved in the metabolism of 25-hydroxycholesterol besides cholesterol 25-hydroxylase.

25-hydroxycholesterol has been found in various organisms such as mice, rats, rabbits, and cows. As of 2023, its presence in other species has not been extensively studied.

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