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ACE inhibitor and thiazide combination

Combination of antihypertensive drugs

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Examples

  • Enalapril/hydrochlorothiazide (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide.
  • Quinapril/hydrochlorothiazide (trade name Accuretic)
  • Lisinopril/hydrochlorothiazide is marketed as Prinzide, Zestoretic, and many others.

Fosinopril/hydrochlorothiazide

Fosinopril/hydrochlorothiazide (trade name Monopril HCT) has a boxed warning about its risk to cause morbidity and mortality in the baby when being used during pregnancy (second and third trimesters).

The FDA modified its labeling in February 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (sodium aurothiomalate) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."

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