Acrokeratosis verruciformis
Medical condition
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Related on Lably
Through Dominance (genetics)
Signs and symptoms
Clinical signs of acrokeratosis include verrucous plaques and flat-topped, polygonal papules. The lesions range in hue from brown to skin tone, and their friction might cause vesicles. The backs of the hands and feet's proximal and distal interphalangeal joints are typically where the lesions are seen. Lesions are less common and only occasionally seen on other body parts. The frontal scalp, flexures, and oral mucosa are not affected by the condition. On the palms and soles, punctate keratosis is another symptom of the illness. Changes to the nails, such as thickening of the nail plate, leukonychia, longitudinal ridges, and nicks in the free edges, are often noted.
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Causes
Acrokeratosis verruciformis is caused by mutations in the ATP2A2 gene and is inherited in an autosomal dominant fashion.
Diagnosis
The diagnosis is established by histological characteristics such as acanthosis, hyperkeratosis, hypergranulosis without parakeratosis, and papillomatosis, which are limited epidermal elevations referred to as "church spires."
Treatment
Superficial ablation is currently the only effective treatment available.

