Aggressive digital papillary adenocarcinoma
Medical condition
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ToursExplore Lably’s 3D toursSigns and symptoms
Aggressive digital papillary adenocarcinoma typically appears as a painless solitary mass on the plantar surface of the feet or palmer surface of the hands.
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Diagnosis
Histologically, the tumor exhibits a mixed tubuloalveolar and papillary pattern, focal squamous metaplasia, fibrocollagenous stroma, and a grenz zone. In situ hybridization for HPV42 DNA may help in differentiating this cancer from related tumors.
The sweat gland adenoid cystic carcinoma, mucinous eccrine carcinoma, and apocrine adenocarcinoma are included in the differential diagnosis.
Treatment
As a first-line surgical strategy, wide local excision with clear resection of margins is advised rather than proximal amputation, and there is currently insufficient evidence to justify the routine use of adjuvant chemotherapy or radiotherapy.
Epidemiology
Aggressive digital papillary adenocarcinoma primarily affects men and is usually diagnosed between the ages of 50 and 70.