Alison Goate
British neuroscientist
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Through Genetics, Alzheimer's disease and Dementia
The Goate Lab studies the genetics and molecular bases of Alzheimer's disease, frontotemporal dementia, and alcoholism.
Education and early career
After receiving her undergraduate degree in biochemistry at the University of Bristol (UK) and her graduate training at Oxford University (UK), Goate studied under Professors Theodore Puck, Professor Louis Lim and Dr. John Hardy. She received a Royal Society University Research Fellowship to conduct research at St. Mary's Hospital Medical School in London.
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Awards and affiliations
She has received the Potamkin Prize from the American Academy of Neurology (1993), the Zenith Award from the Alzheimer's Association, Senior Investigator Award from the Metropolitan Life Foundation, the St. Louis Academy of Science Innovation Award, Carl and Gerty Cori Faculty Achievement Award at Washington University in St. Louis (1994), and a Lifetime Achievement Award from the Alzheimer's Association (2015). She is a fellow of the American Association for the Advancement of Science. She also serves on the faculty of the Hope Center for Neurological Disorders and is an elected member of the National Academy of Medicine. Goate received the Rainwater Prize for Innovation in Neurodegeneration from the Rainwater Charitable Foundation in 2022. Goate was the first female to be awarded the Piepenbrock-DZNE Prize for Neurodegenerative disease research in 2023.
Research
Goate's research centers on the genetics of Alzheimer's disease and related dementias that led to the development of animal and cellular models and the development of anti-amyloid and anti-tau therapies. She has been the principal investigator on four grants and has co-invented and awarded six patents.
Patents
- APP770 mutant in alzheimer's disease, (1999).
- Mutant S182 genes, (1999).
- Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the Alzheimer's S182 gene, (2000).
- Transgenic mouse expressing an APP-FAD DNA sequence, (2001).
- Pathogenic Tau mutations, (2002).
- Markers for addiction, (2011).
Grants
Partial list: