Alpha granule
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Related on Lably
Through Coagulation
Contents
Contents include insulin-like growth factor 1, platelet-derived growth factors, TGF beta, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V, and von Willebrand factor).
The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis.
The other type of granules within platelets are called dense granules.
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Clinical significance
A deficiency of alpha granules is known as gray platelet syndrome.
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