Antidiarrheal

Medical use

Acute diarrhea

Acute diarrhea is a common condition that typically resolves on its own with oral rehydration therapy. Most cases of acute diarrhea are caused by infections from contaminated food or water and usually go away on their own within a week. The most common causes of acute diarrhea in children are the viral agents norovirus and rotavirus, accounting for about 70% of cases. Travelers’ diarrhea (TD) is one of the most common illnesses affecting people of all ages abroad, with up to 70% of travelers developing symptoms within two weeks. While traditional advice like avoiding uncooked or unpeeled foods was once thought to be effective, poor sanitation and food handling practices—especially in local eateries—remain major risk factors.

Anti-motility medications like loperamide and diphenoxylate can help manage the symptoms of travelers’ diarrhea by reducing the frequency of bowel movements, which can be helpful when needing to travel, but are not curative. Loperamide and diphenoxylate should be avoided in people with bloody diarrhea or a fever, and loperamide is typically not recommended for children under six. Additionally, zinc supplements, particularly in children, can reduce diarrheal duration by up to 25% and reduce stool volume by up to 30%.

Dehydration and oral replacement therapy

The primary risk from diarrhea is dehydration and electrolyte loss, making fluid and electrolyte replacement the top treatment priority. Drinking fluids orally is typically as effective as IV fluids and more cost-efficient for most patients. Thus, rehydration is essential when managing acute diarrhea, especially in vulnerable groups like young children, older adults, and those with chronic conditions. Oral rehydration solutions are made with clean water, salt, and sugar. These solutions are ideal for severe cases, while milder dehydration can be managed with safe, preferred fluids—though overly sugary drinks should be avoided.

Dehydration is categorized into three levels: severe, some, or none. Severe dehydration includes signs like lethargy, sunken eyes, little to no urine output, and confusion. Some dehydration may present with dry mouth, restlessness, thirst, and slightly sunken eyes. If these signs are absent or insufficient, the person is not considered dehydrated.

Chronic diarrhea

Chronic diarrhea often persists for greater than a week and may require further work-up from a medical professional. When the underlying cause cannot be directly addressed, long-term symptom management using antidiarrheals is often necessary.