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Aquaporin-3

Protein-coding gene in the species Homo sapiens

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Related on Lably

Through Ammonia

Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes).

Clinical significance

Aquaporin 3 levels are often lower in psoriasis than in healthy skin.

Aquaporin 3 is expressed more in atopic eczema.

Recent studies indicate that aquaporin 3 is overexpressed in many types of malignancies such as melanoma and primary effusion lymphomas as well as cancers of the lung, colon, stomach, esophagus, mouth, liver, and pancreatic duct. Based on these as well as cell culture studies, it is suggested that this overexpression contributes to the growth and spread of at least some of these cancers and therefore may be a therapeutic target for the treatment of these cancers.

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