Bactoprenol
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Through Lipid, Alcohol (chemistry) and Gram-positive bacteria
The double bonds all have the Z configuration except for the three ω-terminal ones, which are biosynthetically derived from (E,E)-farnesyl diphosphate.
Occurrence
Bactoprenol is a lipid synthesized from mevalonic acid and is the most abundant lipid found in certain species of lactobacilli. Bactoprenol is found in both mesosomal and plasma membranes. Mesosomal and plasma bactoprenol are synthesized independently from each other.
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Function
Bactoprenol is thought to play a key role in the formation of cell walls in Gram-positive bacteria by cycling peptidoglycan monomers through the plasma membrane and inserting these monomers at points of growth in the bacterial cell wall.
Antibiotic significance
Because bactoprenol is so important for cell growth, numerous antibiotic compounds function by disrupting the bactoprenol-mediated transportation pathway. This strategy was first identified by studying the antibiotic mechanism of friulimicin B. Since then, other antibiotics that make use of a similar mechanism have been identified, including nisin and lantibiotics such as NAI-107.