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CHAF1B

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Function

Chromatin assembly factor I (CAF-1) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair.

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GenusTaxonomic rank above species and below familyFamily (taxonomy)Taxonomic rank between genus and orderEndemismState of species being unique to a locationCladeGroup of a common ancestor and all of their descendantsGenomeAll genetic material of an organismOrder (taxonomy)Taxonomic rank between class and family