Christiane Nüsslein-Volhard
German developmental biologist and 1995 Nobel Prize winner (born 1942)
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Nüsslein-Volhard earned her PhD in 1974 from the University of Tübingen, where she studied protein-DNA interaction. She won the Albert Lasker Award for Basic Medical Research in 1991 and the Nobel Prize in Physiology or Medicine in 1995, together with Eric Wieschaus and Edward B. Lewis, for their research on the genetic control of embryonic development.
Early life and education
Nüsslein-Volhard was born in Magdeburg on 20 October 1942, the second of five children to Rolf Volhard, an architect, and Brigitte Haas Volhard, a nursery school teacher. She has four siblings: three sisters and one brother. She grew up and went to school in south Frankfurt, where she was exposed to art and music and thus was "trained in looking at things and recognizing things". Her great-grandfather was the chemist Jacob Volhard, and her grandfather was the known internist Franz Volhard. She is also the aunt of the Nobel laureate in chemistry Benjamin List.
After the Abitur in 1962, she briefly considered pursuing medicine, but dropped the idea after doing a month-long nursing course in a hospital. Instead, she opted to study biology at Goethe University Frankfurt. In 1964 Nüsslein-Volhard left Frankfurt for the University of Tübingen, to start a new course in biochemistry. She originally wanted to do behavioral biology, "but then somehow I ended up in biochemistry (...) and molecular genetics because at the time this was the most modern aspect, and I was ambitious — I wanted to go where the leaders were. The old-fashioned botanists and zoologists were such dull people— there was nothing interesting there."
She received a diploma in biochemistry in 1969 and earned a PhD in 1974 for research into protein–DNA interactions and the binding of RNA polymerase in Escherichia coli.
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Career
In 1975, Nüsslein-Volhard became a postdoctoral researcher in Walter Gehring´s laboratory at the Biozentrum, University of Basel. She was a specialist in the developmental biology of Drosophila melanogaster (fruit fly) supported by a long-term fellowship from the European Molecular Biology Organization (EMBO). In 1977, she continued in the laboratory of Klaus Sander at University of Freiburg, who was an expert in embryonic patterning. In 1978, she set up her own lab in the newly founded European Molecular Biology Laboratory in Heidelberg with Eric Wieschaus, whom she had met in Basel. Over the next three years they examined about 20,000 mutated fly families, collected about 600 mutants with an altered body pattern and found that out of the approximately 5,000 essential genes only 120 were essential for early development. In October 1980, they published the mere 15 genes controlling the segmented pattern of the Drosophila larva.
In 1981, Nüsslein-Volhard moved to the Friedrich Miescher Laboratory of the Max Planck Society in Tübingen. From 1984 until her retirement in 2014, she was the director of the Max Planck Institute for Developmental Biology in Tübingen and also led its genetics department. After 1984, she launched work on the developmental biology of vertebrates, using the zebrafish (Danio rerio) as her research model.
In 2001, she became a member of the Nationaler Ethikrat (National Ethics Council of Germany) for the ethical assessment of new developments in the life sciences and their influence on the individual and society. Her primer for the lay-reader, Coming to Life: How Genes Drive Development, was published in April 2006.
In 2004, she started the Christiane Nüsslein-Volhard Foundation (Christiane Nüsslein-Volhard Stiftung) which aids promising young female German scientists with children. The foundation's main focus is to facilitate childcare as a supplement to existing stipends and day care.
Research
During the late 1970's and early 1980's, little was known about the genetic and molecular mechanisms by which multicellular organisms develop from single cells to morphologically complex forms during embryogenesis. Nüsslein-Volhard and Wieschaus identified genes involved in embryonic development by a series of genetic screens, generating random mutations in fruit flies using ethyl methanesulfonate. Some of these mutations affected genes involved in the development of the embryo. They took advantage of the segmented form of Drosophila larvae to address the logic of the genes controlling development. They looked at the pattern of segments and denticles in each mutant under the microscope, and were therefore able to work out that particular genes were involved in different processes during development based on their differing mutant phenotypes (such as fewer segments, gaps in the normal segment pattern, and alterations in the patterns of denticles on the segments). Many of these genes were given descriptive names based on the appearance of the mutant larvae, such as hedgehog, gurken (German: "cucumbers"), and Krüppel ("cripple"). Later, researchers Pavel Tomancak, Amy Beaton, et al., identified exactly which gene had been affected by each mutation, thereby identifying a set of genes crucial for Drosophila embryogenesis.
The subsequent study of these mutants and their interactions led to important new insights into early Drosophila development, especially the mechanisms that underlie the step-wise development of body segments. These experiments are not only distinguished by their sheer scale (with the methods available at the time, they involved an enormous workload), but more importantly by their significance for organisms other than fruit flies.
Her findings led to important realizations about evolution – for example, that protostomes and deuterostomes are likely to have had a relatively well-developed common ancestor with a much more complex body plan than had been conventionally thought.
Additionally, they greatly increased our understanding of the regulation of transcription, as well as cell fate during development.
Nüsslein-Volhard is associated with the discovery of Toll, which led to the identification of toll-like receptors.
As of 2023, Nüsslein-Volhard has an h-index of 104 according to Scopus.
Personal life
Nüsslein-Volhard married in the mid-1960s while studying at the Goethe University Frankfurt, but divorced soon afterward and did not have any children. She lives in Bebenhausen, Germany. She has said that she loves to sing, play the flute and do chamber music. She published a cookbook in 2006.