Clifford Tabin
American geneticist
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Related on Lably
Through Vector (molecular biology), Gene expression and Embryo
Education
Tabin was educated at the University of Chicago where he was awarded a BS in physics in 1976. He went on to graduate school at Massachusetts Institute of Technology and was awarded a PhD in 1984 for work on the regulation of gene expression in the Ras subfamily of oncogenes supervised by Robert Weinberg based in the MIT Department of Biology. In Weinberg's lab, Tabin constructed murine leukemia virus, the first recombinant retrovirus that could be used as a eukaryotic vector.
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Career
Following his PhD, Tabin did postdoctoral research with Douglas A. Melton at Harvard University, then moved to Massachusetts General Hospital where he worked on the molecular biology of limb development. He was appointed to the faculty in the Department of Genetics at Harvard Medical School in 1989, and promoted to full professor in 1997 and chairman of the department in January 2007.
Entrepreneurial activities
In 2023, Dr. Cliff Tabin co-founded Somite Therapeutics, a biotechnology company that integrates artificial intelligence with stem cell biology to develop novel cell replacement therapies.
Research
As of 2014 Tabin's research investigates the genetic regulation of vertebrate development, combining classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene expression during embryogenesis.
Previously Tabin has worked on retroviruses, homeobox genes, oncogenes, developmental biology and evolution. Early in his research he investigated limb regeneration in the salamander, and described the expression of retinoic acid receptor and Hox genes in the blastema. Comparative studies by Ann Burke in his lab showed that differences in boundaries of Hox gene expression correlated with differences in skeletal morphology. The Tabin laboratory adjoins the laboratory of Connie Cepko.
Personal life
Tabin is the son of Julius Tabin, a nuclear physicist who worked with Enrico Fermi on the Manhattan Project in Los Alamos National Laboratory in New Mexico during World War II. He has a brother, Geoff Tabin, and two children. Tabin appears as himself in a BBC Horizon programme titled Hopeful Monsters.