Lably
Skip to content

Complement receptor

Protein family

  • 1 min read
  • 2 chapters

Related on Lably

Through Protein, Adaptive immune system and Gene expression

Lab · Class 11–12Biomolecules of LifeLab · Class 11Biomolecules — Animated Chapter FilmLab · Class 11Locomotion and Movement — Animated Chapter FilmLab · Class 4–6Food and Nutrition

Expression and function

White blood cells, particularly monocytes and macrophages, express complement receptors on their surface. All four complement receptors can bind to fragments of complement component 3 or complement component 4 coated on pathogen surface, but the receptors trigger different downstream activities. Complement receptor (CR) 1, 3, and 4 function as opsonins which stimulate phagocytosis, whereas CR2 is expressed only on B cells as a co-receptor.

Red blood cells (RBCs) also express CR1, which enables RBCs to carry complement-bound antigen-antibody complexes to the liver and spleen for degradation.

a.^B: B cell. E: erythrocyte. Endo: endothelial cell. D: dendritic cell. FDC: follicular dendritic cell. Mac: macrophage. MC: mast cell. M0: monocyte. Pha: phagocyte. PMN: polymorphonuclear leukocyte.

Sign in to keep reading

One more chapter is free with a Lably account.

More in Human body

Anatomical terms of locationStandard terms for unambiguous description of relative placement of body partsPrefrontal cortexPart of the brain responsible for personality, decision-making, and social behaviorPubMedOnline biomedical databaseMucous membraneProtective layer that lines the interior of hollow organsNeuroimagingSet of techniques to measure and visualize aspects of the nervous systemNeuroscientistIndividual who studies neuroscience