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Coronavirus frameshifting stimulation element

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Other RNA families identified in the coronavirus include the coronavirus 3′ stem-loop II-like motif (s2m), the coronavirus packaging signal and the coronavirus 3′ UTR pseudoknot.

During protein synthesis, rapidly changing conditions in the cell can cause ribosomal pausing. In coronaviruses, this can affect growth rate and trigger translational abandonment. This releases the ribosome from the mRNA and the incomplete polypeptide is targeted for destruction.

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