Crithidia luciliae
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Crithidia luciliae is a eukaryotic single-cell protozoan. The family Trypanosomatidae belongs to the order Kinetoplastida and is characterised by the presence of the kinetoplast, a network of interlocking circular DNA in a large mitochondrion. All organisms in Kinetoplastida are parasitic, and the host organism for C. luciliae is the housefly, Musca domestica.
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Role in systemic lupus erythematosus diagnosis
The kinetoplast found in C. luciliae allows them to be used for the detection of anti-dsDNA antibodies, a type of anti-nuclear antibody. Anti-nuclear antibodies are a common feature in SLE, and anti-dsDNA antibodies are highly specific for the disease. The high concentration of dsDNA and the absence of human nuclear antigens in the kinetoplast provides a specific substrate for the detection of anti-dsDNA antibodies.
Purine nucleotide and nucleobase uptake
As a parasitic protozoan, C. luciliae lacks the ability to biosynthetically produce purine bases and therefore needs to salvage them from the surrounding environment. Three transport systems are used for the uptake of bases from the host organism: one for the uptake of adenosine and its analogues; one for guanosine, its analogues and inosine; and one for hypoxanthine, adenine and adenosine.