Diisononyl phthalate
Chemical compound
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Related on Lably
Through Plastic, Reproduction and Aquatic animal
Use
It is commonly used in a large variety of plastic products including:
- Plasticizer in polyvinyl chloride (PVC)
- Construction and building material
- Fuel and automotive products
- In electronics materials (as a flexible vinyl additive)
- As cable insulation additive
- Adhesives and sealants
- Paints and coatings
- Rubber products.
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Health issues
The European Union has set a maximum specific migration limit (SML) from food contact materials of 9 mg/kg food for the sum of diisononyl phthalates and diisodecyl phthalates.
DINP is listed as a substance "known to the State of California to cause cancer" under Proposition 65 legislation.
Studies find that exposure to environmentally relevant concentrations of DINP in zebrafish disrupt the endocannabinoid system (ECS) and affect reproduction in a gender specific manner, and have other adverse effects on aquatic organisms, as DINP upregulates orexigenic signals and causes hepatosteatosis together with deregulation of the peripheral ECS and lipid metabolism.
The ECHA's Risk Assessment Committee (RAC) has concluded, on March 7, 2018, that Di-isononyl phthalate (DINP) does not warrant classification for reprotoxic effects under the EU's Classification, Labelling and Packaging (CLP) regulations.
Children and childcare products are strictly regulated by regulatory organizations.