Direct repeat

5´ TTACGnnnnnnTTACG 3´

3´ AATGCnnnnnnAATGC 5´

Linguistically, a typical direct repeat is comparable to saying "bye-bye".

Types

There are several types of repeated sequences:

• Interspersed (or dispersed) DNA repeats (interspersed repetitive sequences) are copies of transposable elements interspersed throughout the genome.
• Flanking (or terminal) repeats (terminal repeat sequences) are sequences that are repeated on both ends of a sequence, for example, the long terminal repeats (LTRs) on retroviruses. Direct terminal repeats are in the same direction and inverted terminal repeats are opposite to each other in direction.
• Tandem repeats (tandem repeat sequences) are repeated copies which lie adjacent to each other. These can also be direct or inverted repeats. The ribosomal RNA and transfer RNA genes belong to the class of middle repetitive DNA.

Microsatellite DNA

A tract of repetitive DNA in which a motif of a few base pairs is tandemly repeated numerous times (e.g. 5 to 50 times) is referred to as microsatellite DNA. Thus direct repeat tandem sequences are a form of microsattelite DNA. The process of DNA mismatch repair plays a prominent role in the formation of direct trinucleotide repeat expansions. Such repeat expansions underlie several neurological and developmental disorders in humans.