Don Mason (immunologist)

Notable work

Although Mason began his research career as a physicist studying controlled thermonuclear fusion, he is best known for his work on cellular immunology, summarised in outline here. Mason's most important contributions to immunology were his studies defining the existence, cell surface phenotype and function of regulatory T cells. Mason's research identified the immuno-regulatory capacity of a population of CD4+ T cells that express low levels of OX22 (an isoform of CD45: CD45RC in rats and CD45RB in mice) and their capacity to prevent the pathogenic activity of the OX22hi subset. While he carried out studies into multiple sclerosis, the work for which he is most recognised focused mainly on the role of Tregs in the prevention of diabetes and thyroiditis and highlighted the role for the thymus in the development of Tregs. These were among the earliest demonstrations of the requirement for Treg in restraining the pathogenic activity of CD4+ T cells and prevention of autoimmunity. Mason retired from research in 1999.