Dorothy P. Schafer
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- 3 chapters
Related on Lably
Through Neurotransmission, Schizophrenia and Alzheimer's disease
Early life and education
Schafer earned a BA in Neuroscience from Mount Holyoke College in 2001. She completed her PhD in 2008 at the University of Connecticut, where she worked with Matthew Rasband at the University of Connecticut Health Center. From 2008 to 2014, Schafer worked as a postdoctoral fellow in Beth Stevens's lab at Boston Children's Hospital.
In January 2015, Schafer was hired as a tenure-track assistant professor of neurobiology at UMass Medical School.
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Research
Microglia-synapse interactions
Schafer has studied the phagocytic function of microglia, which is required for synaptic pruning of the connections between the retina and the lateral geniculate nucleus, as well as other highly organized pathways in the healthy central nervous system. The pruning ability of microglia is dependent on complement component 3. Schafer's current research includes ablating genes of interest in microglia to determine their effects on synaptic structure as well as behavior.
Microglial cytokine signaling also modulates synaptic function by regulating neurotransmitter receptor expression, which can directly impact neurotransmission. Alongside Beth Stevens, Schafer has proposed an expansion to the tripartite synapse model of neural function called the quad-partite synapse.
Neurological disease
Microglia are implicated in the development of neuropsychiatric and neurodegenerative diseases such as autism, schizophrenia, ALS, and MS. In a MECP2-null mouse model of Rett syndrome, Schafer demonstrated that microglia contributed to disease by excessively pruning presynaptic inputs, thereby disrupting vulnerable neural circuits. Microglia functioned primarily as "secondary responders" which were excessively activated by disease, a mechanism which may be conserved in other models of neurodegeneration like Alzheimer's disease.
Awards
Schafer has received funding and recognition for her academic work, including the following awards:
- 2017-2019 Young Investigator Grant, NARSAD
- 2016-2018 Child Health Research Award, Charles H. Hood Foundation
- 2016-2017 Biomedical Research Award, Worcester Foundation for Biomedical Research
- 2014-2018 K99/R00 Career Transition Award, NIMH
- 2012-2013 Postdoctoral Fellowship Award, Nancy Lurie Marks Family Foundation
- 2010-2011 Bok Center distinction for excellence in teaching, Harvard University
- 2010-2012 NRSA F32 Postdoctoral Fellowship, NINDS
- 2010-2011 Marian Kies Award for outstanding graduate work, American Society for Neurochemistry
- 2007 Lepow Award for outstanding graduate work, University of Connecticut Health Center