Edith Heard
British epigenetics researcher
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- 4 chapters
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Through Placenta, Embryo and Chromosome
From 2010 to 2018, Heard was the Director of the Genetics and Developmental Biology department at the Curie Institute (Paris), France. Heard is noted for her studies of X-chromosome-inactivation.
Education
Heard attended Francis Holland, Regent's Park, a private girls' school in central London. She graduated with a Bachelor of Arts degree in Natural Sciences (Genetics) from the University of Cambridge as a student of Emmanuel College, Cambridge, graduating in 1986. She was awarded a PhD from Imperial College London for research investigating gene amplification in rat cells in 1990 while working at the Imperial Cancer Research Fund Laboratory in London, UK.
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Career and research
Heard's main areas of research include genetics, epigenetics and developmental biology, in particular focussing on X-chromosome inactivation, which occurs when one of the two copies of the X chromosomes in female mammals is inactivated. Her work on this process started in the 1990’s during her post-doc in the laboratory of Philip Avner at the Pasteur Institute. After joining the CNRS, she continued to work on X inactivation, performing functional studies on the X-inactivation centre locus that regulates the initiation of X inactivation. In 2000, Heard spent a year as a visiting scientist in David Spector’s group at Cold Spring Harbor Laboratory where she discovered some of the early chromatin changes in the X-inactivation process.
Heard set up her own laboratory at the Institut Curie in 2001. Amongst her contributions, her group showed that X-chromosome inactivation happens not once, but twice, during development: first in all cells designated to building the placenta, then again in some cells sent off to build the embryo.
Heard developed powerful single-cell techniques enabling the analysis of fixed and living embryos and embryonic stem cells. These led to one of her major discoveries, showing that X-inactivation is a highly dynamic process during early embryogenesis and revealing major differences in X-inactivation strategies in different mammals, from mouse to man. Heard has also performed pioneering work revealing that in addition to epigenetic modifications, chromosome organization and nuclear compartmentalization are important players in the initiation and maintenance of X inactivation. Thanks to their studies on the X-inactivation centre, the Heard group also revealed the existence of Topologically Associating Domains (TADs) in collaboration with Job Dekker.
Heard has been a professor at the Collège de France, holding the Chair of Epigenetics and Cellular Memory, and from 2010 to 2018 she was director of the Genetics and Developmental Biology department at the Institut Curie in Paris. She and her laboratory moved to EMBL in 2019. In 2016, Heard was involved in establishing a Government of France programme to support scientists displaced by war or conflict – the Programme d'aide à l'accueil en urgence des scientifiques en exil (PAUSE).
In June 2017, Heard's appointment as the fifth Director General of the European Molecular Biology Laboratory was announced, and she took office in January 2019. In July 2024, Heard was announced as the second Director and CEO of the Francis Crick Institute and she took up the post in September 2025.
Other activities
Heard is a member of the Scientific Advisory Board of the Biotech Research & Innovation Centre (Copenhagen, Denmark), the Institute of Molecular Biology and Biotechnology (Crete, Greece) and Aithyra, the Research Institute for Biomedical Artificial Intelligence of the Austrian Academy of Sciences. She is also a Trustee of the Howard Hughes Medical Institute and Institut Imagine (Paris, France).
Heard was a member of the Francis Crick Institute Scientific Advisory Board from 2016 until her announcement as incoming Director.
She has served as a member of the science council of the World Health Organization (WHO) since 2021.
Personal life
Heard is married to French molecular biologist Vincent Colot. They have two children.