Feminization (biology)

Pathological feminization

In animals, when feminization occurs in a male, or at an inappropriate developmental age, it is often due to a genetic or acquired disorder of the endocrine system. In humans, one of the more common manifestations of abnormal feminization is gynecomastia, the inappropriate development of breasts which may result from elevated levels of feminizing hormones such as estrogens. Deficiency or blockage of virilizing hormones (androgens) can also contribute to feminization. In some cases, high levels of androgens may produce both virilizing effects (increased body hair, deepened voice, increased muscle mass, etc.) and feminizing effects (gynecomastia) since androgens can be converted to estrogens by aromatase in the peripheral tissues.

In insects, feminization can occur through inheritance of reproduction-manipulating endosymbionts. This promotes the inheritance of the endosymbionts because the endosymbionts are passed on by mothers to their eggs. As such, the more endosymbiont-infected females there are in a population, the more the endosymbionts are passed on to the next generation.