HCN1
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Function
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.
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Tissue distribution
HCN1 channel expression is found in the sinoatrial node, the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.
Ligands
- Ketamine is an inhibitor of HCN1 in addition to its other targets.
- Propofol also inhibits HCN1.
- Isoflurane and Sevoflurane inhibit HCN1.
Interactions
HCN1 has been shown to interact with HCN2.
Epilepsy
De novo mutations in HCN1 cause epilepsy.
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