HLA-C
Protein-coding gene in the species Homo sapiens
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ToursExplore Lably’s 3D toursHLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.
Disease associations
By serotype
Cw1: multinodular goiters
By allele
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Nomenclature
C*01
- Cw1 serotype: C*01:02 and C*01:09
- Cw11
- C*01:04 to *01:08
C*02
- Cw2 serotype: C*02:02 and *02:08
- C*02:03 to *02:07, and 02:09
C*03
- Cw9 serotype: C*03:03
- Cw10 serotype: C*03:02, *03:04, and *03:06
- Cw3 serotype: C*03:07
- C*03:05 and 03:08
C*04
- Cw4 serotype: C*0401, *0407, and *0410
C*05
- Cw5 serotype: C*05:01 and *05:02
- C*05:03 to *05:06 and *05:08 to *05:10
C*06
- Cw6 serotype: C*06:02 and *06:05
- C*06:03, *06:04 and *06:06 to *06:11
C*07
- Cw7 serotype: C*07:01 to *07:06, *07:12, *07:14, *07:16
- C*07:07 to *07:11, *07:13, *07:15, and *07:17 to *07:29
C*08
- Cw8 serotype: C*08:01, *08:02 and *08:03
- C*08:05 to *08:12
Others
- C*12:02 to *12:15
- C*14:02 to *14:05
- C*15:01 to *15:11
- C*16:01 to *16:06
- C*17:01 to *17:03
- C*18:01 and *18:02
Common haplotype
Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)
Interactions
HLA-C has been shown to interact with:
- KIR2DL1,
- Leukocyte immunoglobulin-like receptor family:
- particularly the activating receptor LILRA1
- LILRA3
More in Biology
GenusTaxonomic rank above species and below familyFamily (taxonomy)Taxonomic rank between genus and orderEndemismState of species being unique to a locationCladeGroup of a common ancestor and all of their descendantsGenomeAll genetic material of an organismOrder (taxonomy)Taxonomic rank between class and family