Kininogen 1
Protein-coding gene in the species Homo sapiens
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Through Protein, Gene and Coagulation
Expression
The KNG1 gene uses alternative splicing to generate two different proteins: high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK). HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin.
- KNG1 gene → low-molecular-weight kininogen (LMWK) protein (contains 427 amino acids) or high-molecular-weight kininogen (HMWK) protein (644 amino acids)
- HMWK protein → bradykinin peptide (9 amino acids)
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Function
HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation.
Kininogen-1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.
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