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Leukotriene B4

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Biochemistry

LTB4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue. In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosomal enzymes by these cells. It is synthesized by leukotriene-A4 hydrolase from leukotriene A4.

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GenusTaxonomic rank above species and below familyFamily (taxonomy)Taxonomic rank between genus and orderEndemismState of species being unique to a locationCladeGroup of a common ancestor and all of their descendantsGenomeAll genetic material of an organismOrder (taxonomy)Taxonomic rank between class and family