Negativicutes
Class of bacteria
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Through Bacteria, Gram-negative bacteria and Banana
Most members of this class are obligate anaerobes, and occur in habitats such as rivers, lakes, and the intestines of vertebrates. They range from spherical forms, such as Megasphaera and Veillonella, to curved rods, as typified by the selenomonads. Selenomonas has a characteristic crescent shape, with flagella inserted on the concave side, while Sporomusa is similar, but nonmotile. Their names refer to this distinctive morphology: selene means moon, and musa means banana.
Taxonomy
The class currently consists of 32 validly named genera across three orders and four families. The orders Veillonellales and Acidaminococcales each contain a single family, Veillonellaceae and Acidaminococcaceae, respectively, while the order Selenomonadales contains two families, Selenomonadaceae and Sporomusaceae.
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Molecular signatures
Historically, the Negativicutes consisted of a single order, the Selenomonadales, and two families, Veillonellaceae and Acidaminococcaceae based on 16S rRNA gene sequence similarity. However, these groupings did not include several members within the Negativicutes that branched outside of the two families. The current taxonomic view is inclusive of these members who have been validly assigned to the families Selenomonadaceae and Sporomusaceae within the emended Selenomonadales order. Molecular markers in the form of conserved signature indels (CSIs) and proteins (CSPs) justify the present taxonomic divisions. These molecular markers are found at each taxonomic rank, and their distribution is in agreement with the observed phylogenetic branching.
Many works have implicated that the Negativicutes should be reclassified as an order within the class Clostridia, based on close phylogenetic branching, and the observation that the spore-forming members of the Negativicutes share similar sporulation genes as the Clostridia, and that both stain gram-negative. However, the heterogeneity of members within the Negativicutes, as well as the distribution of molecular signatures, supports the view that the Negativicutes are in fact an independent class within the Bacillota, with Clostridia as their closest phylogenetic neighbours. Additionally, several CSIs and CSPs have been found to be uniquely shared among all Negativicutes, while no CSIs have been found to be shared by both Negativicutes and Clostridia.
Phylogeny
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN) and National Center for Biotechnology Information (NCBI).