Neil Brockdorff
British biochemist (born 1958)
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Through Biochemistry, Gene and Genome
Education
Brockdorff was educated at Hampstead School, the University of Sussex (BSc) and the University of Glasgow (PhD).
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Career and research
X inactivation is an important model for understanding how epigenetic mechanisms, for example modification of DNA and histone proteins around which DNA is packaged, contribute to gene regulation in developmental biology. In earlier work Brockdorff demonstrated that an unusual functional RNA molecule, XIST, controls the X inactivation process. Building on this finding he has elucidated key steps in XIST gene regulation during early development, and has defined major pathways through which XIST RNA induces chromosome wide gene silencing.