Neuropeptide S
Protein-coding gene in the species Homo sapiens
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Synthetic ligands
The non-peptide NPS receptor antagonist SHA-68 blocks the effects of NPS in animals and is anxiogenic. Several peptide derived NPS agonists and antagonists have also been developed.
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Peptide sequence
Below are the sequences of mature neuropeptide S in several representative species in which it is expressed:
According to Pfam's HMM logo, there is a conserved "KR" cleave site immediately N-terminal to the C-terminal mature peptide.
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