Neurophysiological Biomarker Toolbox

In a nutshell

The Neurophysiological Biomarker Toolbox (NBT) is an open source MATLAB toolbox for the computation and integration of neurophysiological biomarkers (e.g., biomarkers based on EEG or MEG recordings). The NBT toolbox has so far been used in seven peer-reviewed research articles, and has a broad user base of more than 1000 users. The NBT toolbox provides unique features for analysis of resting-state EEG or MEG recordings. NBT offers a pipeline from data storage to statistics including artifact rejection, signal visualization, biomarker computation, statistical testing, and biomarker databasing. NBT allows for easy implementation of new biomarkers, and incorporates an online wiki (the NBTwiki) that aims at facilitating collaboration among NBT users including extensive help and tutorials. The standardised way of data storage and analysis that NBT proposes allow different research projects to merge, compare, or share their data and biomarker algorithms.

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Features

Neuronal oscillations are generated at many spatial and temporal scales of neuronal organization, and thought to provide a network-level mechanism for the coordination of spatio-temporally distributed spiking activity. For an adequate understanding of quantitative changes in neurophysiological signals, such as electroencephalography (EEG) or magnetoencephalography (MEG), as a consequence of disease, experimental manipulations, or genetic variability there is a need to apply multiple biomarker algorithms.

The aim of the NBT toolbox is to make biomarker research easier at all levels. From having raw data, cleaning it, calculating biomarkers, to performing advanced statistics.

The NBT toolbox includes biomarkers, such as:

Standard spectral biomarkers
Phase locking value
Detrended fluctuation analysis

The toolbox has a standard template for how biomarkers should be implemented, which makes it relatively easy to implement new biomarkers. Originally the toolbox was aimed at biomarkers based on EEG or MEG signals, recently however the toolbox has moved towards supporting almost any type of biomarker data.

The biomarker data and associated meta information is stored in a Matlab-based database; the NBT elements database.

The NBT toolbox works as a plugin to the open-source Matlab toolbox EEGLAB.

Commercial EEG analysis mainly targeting large clinical research studies or clinical trials are provided as an service to NBT toolbox by NBT Analytics.

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Neurophysiological Biomarker Toolbox

Features

History

Scientific publications using the NBT toolbox

More in Human body