Precursor B-cell lymphoblastic leukemia
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Related on Lably
Through Blood
Subtypes
It consists of the following subtypes:
- t(9;22)-BCR/ ABL
- t(v;11q23)-MLL rearrangement
- t(1;19)-E2A/PBX1
- t(12;21)-ETV/ CBFα
- t(17;19)-E2A-HLF
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Molecular mechanisms
One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells. In approximately two-thirds of pediatric B-ALL patients, specific chromosomal translocations and their fusion genes are detectable, and these fusion genes play crucial roles as risk factors for strategic treatment. More than 200 fusion genes or mutated genes have been identified in ALL patients to date.
Diagnosis
t(12;21)-ETV/ CBFα has a better prognosis as compared to other subtypes.
Treatment
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