Pure red cell aplasia
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Related on Lably
Through Red blood cell, Virus and Autoimmunity
Signs and symptoms
Signs and symptoms may include:
- Pale appearance
- Rapid heart rate
- Fatigue
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Causes
Causes of PRCA include:
- Autoimmune disease.
- Thymoma.
- Viral infections such as HIV, herpes, parvovirus B19 (Fifth disease), or hepatitis.
- Lymphoproliferative. Association of pure red cell aplasia with T-cell large granular lymphocyte leukemia is well recognized, especially in China.
- Idiopathic. Many cases of PRCA are considered idiopathic in that there is no discernible cause detected.
- Drugs such as mycophenolic acid or erythropoietin.
- Congenital. The term "hereditary pure red cell aplasia" has been used to refer to Diamond–Blackfan anemia.
Diagnosis
Treatment
PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as cyclosporin in many patients, though this approach is not without risk.
It has also been shown to respond to treatments with rituximab and tacrolimus.
For cases related to B19 parvovirus, administration of commercial immunoglobulin can treat or cure parvovirus by replacing neutralizing antibodies.
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