Lably
Skip to content

Rosehip neuron

Type of inhibitory neuron in the human cerebral cortex

  • 1 min read
  • 1 chapter

Related on Lably

Through Neuron

Lab · Class 11Neural Control and Coordination — Animated Chapter FilmLab · Class 10–11Neural ControlLab · Class 11One Day Inside the Human Body — Animated Chapter FilmLab · Class 10Control and Coordination

Rosehip neurons are named after the rose hip fruit due to the axon terminal's resemblance to their berries.

These rosehip cells show an immunohistochemical profile (GAD1+CCK+, CNR1–SST–CALB2–PVALB–) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. Rosehip cells in layer 1 make homotypic gap junctions, predominantly target apical dendritic shafts of layer 3 pyramidal neurons, and inhibit backpropagating pyramidal action potentials in microdomains of the dendritic tuft. These cells are therefore positioned for potent local control of distal dendritic computation in cortical pyramidal neurons.

Discovery

An international group of scientists discovered Rosehip neurons and announced their discovery in August 2018. These authors contributed equally to this work: Eszter Boldog (University of Szeged, Szeged, Hungary), Trygve E. Bakken (Allen Institute for Brain Science, Seattle, WA, United States), and Rebecca D. Hodge (Allen Institute for Brain Science, Seattle, WA, United States). They identified this cell with the help of RNA sequencing.

More in Neuroscience

StriatumNucleus in the basal ganglia of the brainBrain-derived neurotrophic factorProtein found in humansOrbitofrontal cortexRegion of the prefrontal cortex of the brainVentral tegmental areaGroup of neurons on the floor of the midbrainSlow-wave sleepPeriod of sleep in humans and other animalsVascular endothelial growth factorProtein involved in blood vessel growth