Sf9 (cells)

Sf9 cell lines are widely utilized in the manufacture of recombinant protein antigens, including certain COVID-19 vaccines (like NVX-CoV2373 or ZF2001). Because subunit vaccines contain only specific viral components, they are generally considered safe for use across diverse demographic groups, including individuals with reduced immune function, as well as children and older adults. An additional practical advantage of this vaccine type is its stability, allowing for easier storage and distribution.

Sf9 Rhabdovirus

It has previously been shown that some Sf9 cell lines harbor a negative sense Rhabdovirus called Spodoptera frugiperda rhabdovirus (SfRV). However, not all tested Sf9 cells appear to be infected with this virus. SfRV appears to be insect-specific and does not appear to infect mammalian cell lines.