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SV2A

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SV2A is the most widely expressed isoform of the SV2 family (which also includes the SV2B and SV2C proteins) found in all brain regions. The role of the SV2 proteins is not well understood, however they are thought to be involved in regulating vesicular processes.

The SV2A protein is a target of the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam but it is not clear how these drug affect SV2A activity.

Localisation

SV2A is differentially expressed in both inhibitory GABAergic and excitatory glutamatergic terminals however it is not expressed in all synapses as was previously thought. There is a slightly stronger colocalisation between SV2A and GABA than glutamate and the association differs across brain regions and changes with developmental stages.

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Source and licence. Adapted from the Wikipedia article “SV2A” (this version, 2024-10-02) by its contributors, shared under CC BY-SA 4.0. Lablypedia has left out its tables, references and most pictures, and linked it to other Lablypedia articles.