Tobacco and other drugs

Causation model

A 1994 report from the Center on Addiction and Substance Abuse at Columbia University found a correlation between the use of cigarettes and alcohol and the subsequent use of cannabis. The report asserted a link between alcohol and cannabis use and the subsequent use of illicit drugs like cocaine. It found that when younger children used, the more often they use them, the more likely they were to use cocaine, heroin, hallucinogens and other illicit drugs. The report concludes that the data is already robust enough to make a strong case to step up efforts to prevent childhood use of cigarettes and to take firm steps to reduce children’s access to these "gateway drugs".

Researchers have found that craving nicotine also increases craving for illicit drugs among people who use substances who smoke tobacco, and this suggests that people who smoke in drug rehabilitation programs may be less successful in abstaining from other substances than people who do not smoke while in rehabilitation.

In mice, nicotine increased the probability of later consumption of cocaine. The experiments permitted concrete conclusions on the underlying molecular biological alteration in the brain. The biological changes in mice correspond to the epidemiological observations in humans that nicotine consumption is coupled to an increased probability of later use of cocaine.