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Tolerability

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As an example, tricyclic antidepressants (TCAs) are very poorly tolerated and often produce severe side effects including sedation, orthostatic hypotension, and anticholinergic effects, whereas newer antidepressants have far fewer adverse effects and are well tolerated.

Drug tolerability should not be confused with drug tolerance, which refers to subjects' reduced reaction to a drug following its repeated use.

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