Tropic acid
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Through International Union of Pure and Applied Chemistry and Sulfuric acid
Synthesis
Tropic acid can be prepared by the Ivanov reaction between phenylacetic acid and formaldehyde. In this method, the dianion of the acid is formed using a Grignard reagent, isopropyl magnesium chloride, and this reacts with the aldehyde to form the magnesium salt of the product, from which the pure acid is obtained after acidification with sulfuric acid.
Many other methods have been used to make tropic acid, for example starting from acetophenone (1).
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Uses
Tropic acid is used in the chemical synthesis of atropine and hyoscyamine.
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