Type I cytokine receptor

The common cytokine-binding domain is related to the Fibronectin type III domain.

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.

• The IL-2 receptor common gamma chain (also known as CD132) is shared between:
  • IL-2 receptor
  • IL-4 receptor
  • IL-7 receptor
  • IL-9 receptor
  • IL-13 receptor
  • IL-15 receptor
  • IL-21 receptor
• The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
  • GM-CSF receptor
  • IL-3 receptor
  • IL-5 receptor.
• The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
  • IL-6 receptor
  • IL-11 receptor
  • IL-12 receptor
  • IL-27 receptor
  • Leukemia inhibitory factor receptor
  • Oncostatin M receptor