Vascular organ of lamina terminalis
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Through Sense, Circulatory system and Sodium
It is one of the three sensory circumventricular organs of the brain. The other four are secretory.
Anteroventral third ventricle region
The VOLT, median eminence, and subfornical organ are interconnected with the mid-ventral hypothalamus, and together these three structures surround the third ventricle, a complex often called the anteroventral region of the third ventricle ("AV3V" region). This region functions in the regulation of fluid and electrolyte balance by controlling thirst, sodium excretion, blood volume regulation, and vasopressin secretion.
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Function
The VOLT is one of the three sensory circumventricular organs providing information to other brain regions.
VOLT capillaries do not have a blood–brain barrier, and so neurons in this region can respond to circulating factors present in the systemic circulation.
Neurons in the VOLT are osmoreceptors sensitive to the sodium content and osmotic pressure of blood. Neurons of the lamina terminalis project to the supraoptic nucleus and paraventricular nucleus to regulate the activity of vasopressin-secreting neurons. In a situation of lowered blood volume, secretion of renin by the kidneys results in the production of angiotensin II, which stimulates receptors in the VOLT and subfornical organ to complete a positive feedback loop. These neurons also project to the median preoptic nucleus which is involved in controlling thirst.