Veena Parnaik

Research

Dr. Parnaik's research is mainly concerned with understanding the functional role of the nuclear lamina, not to be confused with the basal lamina which provides structural support to the extracellular matrix. The nuclear lamina provides structural support to the nucleus and is invaluable in its role in cell differentiation in the embryonic stage and its role in regulating certain cellular events such as cell division and DNA replication. Although her research is concerned with the functional role of the nuclear lamina the applications of her research may provide insight into the causes and genetic origins of laminopathies.

Laminopathies

Laminopathies are a group of rare genetic disorders that are caused by defects in genes that code for the nuclear lamina. Symptoms of laminopathy may include muscular dystrophy, diabetes, dysplasia and progeria (premature aging). Although there are a number of rare mutations that may result in laminopathy one of the most well researched causes is a mutation in the gene coding for lamin A/C (LMNA). Dr. Parnaik's research is concerned with discovering the cause of a number of defects on the nuclear level that result from mutations in LMNA that include failure to differentiate in adipose tissue, impaired nuclear integrity, impairment in the cell's ability to respond to DNA damaging agents, and cellular toxicity which may lead to premature aging.

Nuclear Lamins

A large role of Dr. Parnaik's research into the nuclear lamina is focused on the nuclear lamins, fibrous proteins found in the nuclear lamina that provide structural support and are essential for proper cell differentiation and gene regulation. Through her research, Dr. Parnaik has made considerable progress in understanding the role of nuclear lamins during embryonic development. She identified human lamin A/C as being invaluable to proper embryonic development by demonstrating that depletion leads to improper cell differentiation in stem cells. In cells where lamin A/C has been depleted the stem cells fail to differentiate into endoderm, mesoderm and ectoderm. In addition to stem cell differentiation, Dr. Parnaik's research has also shown a relationship between lamin A/C and cyclin D3. From her research, Dr. Parnaik pointed towards a complex that formed between lamin A/C and cyclin D3 that played an important role in muscle cell differentiation. Dr. Parnaik's research may pave the way to new understanding of how cell's differentiate in the embryonic stage and may provide insight into how mutations and deletions in these molecules may explain certain embryonic defects and failures to differentiate.

Honors and awards

Dr. Parnaik has served on the Executive Committee of the Indian Society of Cell Biology for numerous years (1991-1994, 2003-2005, and 2007-2009) and she served as the president of the Society from 2011 to 2013. In 2004 she was elected Fellow of the Indian National Science Academy in New Delhi and in 2008 she was elected Fellow of the Indian Academy of Sciences in Bangalore. In 2011 she received the JC Bose Fellowship. Dr. Parnaik has also received a number of prestigious awards including the Shakuntala Devi Amirchand Prize of ICMR (1992), the Dr. PA Krup Lecture Award of Society of Biological Chemists for India (1997) and the Professor SP Ray-Chaudhuri Lecture Award of Indian Society of Cell Biology (2010).