Lably
Skip to content

2′-CH3-MPTP

Dopaminergic neurotoxin

  • 1 min read
  • 1 chapters

Related on Lably

Through Scientific method and Neuron

Lab · Class 6–12Sociology: Individual & SocietyLab · Class 11Neural Control and Coordination — Animated Chapter FilmLab · Class 10–11Neural ControlLab · Class 11One Day Inside the Human Body — Animated Chapter Film

2′-CH3-MPTP is metabolized by monoamine oxidase A (MAO-A) and B (MAO-B) and this biotransformation is required for its dopaminergic neurotoxicity. Whereas the dopaminergic neurotoxicity of MPTP is completely prevented by the MAO-B inhibitor selegiline, complete prevention of 2′-CH3-MPTP's dopaminergic neurotoxicity requires combined treatment with both selegiline and the MAO-A inhibitor clorgyline.

A close analogue of 2′-CH3-MPTP is 2′-NH2-MPTP, which, in contrast to 2′-CH3-MPTP and MPTP, is a serotonergic and noradrenergic neurotoxin with no effect on dopaminergic neurons. Numerous other neurotoxic MPTP analogues have also been synthesized.

2′-CH3-MPTP was first described in the scientific literature by 1986.

More in Neuroscience

StriatumNucleus in the basal ganglia of the brainBrain-derived neurotrophic factorProtein found in humansOrbitofrontal cortexRegion of the prefrontal cortex of the brainVentral tegmental areaGroup of neurons on the floor of the midbrainSlow-wave sleepPeriod of sleep in humans and other animalsVascular endothelial growth factorProtein involved in blood vessel growth