Acetochlor
Weed control herbicide
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Through Weed and Carcinogen
Manufacture
Acetochlor is manufactured in two steps from 2-ethyl-6-methylaniline. A reaction with chloroacetyl chloride gives an anilide which is treated with chloromethyl ethyl ether and sodium hydroxide to form the herbicide.
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Uses
In the United States, acetochlor was registered by the EPA as a direct substitute for many herbicides of known concern. The EPA imposed several restrictions and conditions on the use of acetochlor.
It is approved for pre-emergence application or for pre-planting application with soil incorporation, in corn. (maize) at 5 litres / hectare (1835g / hectare of a.i.) It is the main active ingredient in Acenit, Keystone, Guardian, Harness, Relay, Sacemid, Surpass, Top-Hand, Trophy and Winner.
It is used to control weeds in corn, and is particularly useful as a replacement for atrazine in the case of some important weeds.
Internationally
It is also registered in South Africa.
Safety
Acetochlor has been classified as a probable human carcinogen. Acetochlor, as alachlor, can cause nasal turbinate tumors via the generation of a common tissue reactive metabolite that leads to cytotoxicity and regenerative proliferation in the nasal epithelium.
It is a thyroid disruptor.
Human health effects from acetochlor at low environmental doses or at biomonitored levels from low environmental exposures are unknown. A case of poisoning with extremely swollen genitals as a symptom was reported after contact.
Ecologic effects
In the United States, acetochlor is the third most frequently detected herbicide in natural waters.
Acetochlor can accelerate metamorphosis in amphibians. It can also affect the development of fish.