Aminophosphonate

Phosphonates are more difficult to hydrolyse than phosphates. Some aminophosphonates degrade to aminomethylphosphonic acid.

Preparation

Aminophosphonates are often prepared by hydrophosphonylation, usually the condensation of imines and phosphorous acid. In the Pudovik reaction or Kabachnik–Fields reaction, the esters of phosphorous acid are employed, e.g. diphenylphosphite. Because these compounds are of pharmaceutical interest, methods have been developed to induce these additions asymmetrically.