Apothecaries' system

Medical prescriptions

Until around 1900, medical prescriptions and most European pharmacopoeias were written in Latin. Here is a typical example from the middle of the 19th century.

The letters "ss" are an abbreviation for the Latin "semis" meaning "half", which were sometimes written with a ß. In Apothecaries' Latin, numbers were generally written in Roman numerals, immediately following the symbol. Since only the units of the apothecaries' system were used in this way, this made it clear that the civil weight system was not meant.

Variants

Diversity of local standards

The basic form of the apothecaries' system is essentially a subset of the Roman weight system. An apothecaries' pound normally consisted of 12 ounces. (In France this was changed to 16 ounces, and in Spain, the customary unit was the marco, a mark of 8 ounces.) In the south of Europe and in France, the scruple was generally divided into 24 grains, so that one ounce consisted of 576 grains. Nevertheless, the subdivision of an ounce was somewhat more uniform than that of a pound, and a common feature of all variants is that 12 ounces are roughly 100 drachms (96–128 drachms) and a grain is roughly the weight of a physical grain.

It is most convenient to compare the various local weight standards by the metric weights of their ounces. The actual mass of an ounce varied by ±17% (5 g) around the typical value of 30 g. The table only shows approximate values for the most important standards; even the same nominal standard could vary slightly between one city and its neighbour. The range from 25 g to 31 g is filled with numerous variants, especially the Italian range up to 28 g. But there is a relatively large gap between the troy ounces of 31 g and the Habsburg ounce of 35 g. The latter is the product of an 18th-century weight reform.

Even in Turkey a system of weights similar to the European apothecaries' system was used for the same purpose. For medical purposes the tcheky (approx. 320 g) was divided in 100 drachms, and the drachm in (16 kilos or) 64 grains. This is close to the classical Greek weight system, where a mina (corresponding roughly to a Roman libra) was also divided into 100 drachms.

With the beginning of metrication, some countries standardized their apothecaries' pound to an easily remembered multiple of the French gramme. E.g. in the Netherlands the Dutch troy pound of 369.1 g was standardized in 1820 to 375.000 g, to match a similar reform in France. The British troy pound retained its value of 373.202 g until in 2000 it was legally defined in metric terms, as 373.2417216 g. (At this time its use was mainly confined to trading precious metals.)

Basic variants

In the Romance speaking part of Europe the scruple was divided in 24 grains, in the rest of Europe in 20 grains. Notable exceptions were Venice and Sicily, where the scruple was also divided in 20 grains.

The Sicilian apothecaries ounce was divided into 10 drachms. Since the scruple was divided into only 20 grains, like in the northern countries, an ounce consisted of 600 grains. This was not too different from the situation in most of the other Mediterranean countries, where an ounce consisted of 576 grains.

In France, at some stage the apothecaries' pound of 12 ounces was replaced by the larger civil pound of 16 ounces. The subdivisions of the apothecaries ounce were the same as in the other Romance countries, however, and were different from the subdivisions of the otherwise identical civil ounce.

Origins

Roman weight system

The basic apothecaries' system consists of the units pound, ounce, and scruple from the classical Roman weight system, together with the originally Greek drachm and a new subdivision of the scruple into either 20 ("barley") or 24 ("wheat") grains (Latin: grana). In some countries other units of the original system remained in use, for example in Spain the obolo and siliqua. In some cases the apothecaries' and civil weight systems had the same ounces ("an ounce is an ounce"), but the civil pound consisted of 16 ounces. Siliqua is Latin for the seed of the carob tree.

Many attempts were made to reconstruct the exact mass of the Roman pound. One method for doing this consists in weighing old coins; another uses the fact that Roman weight units were derived from Roman units of length similar to the way the kilogramme was originally derived from the metre, i.e. by weighing a known volume of water. Nowadays the Roman pound is often given as 327.45 g, but one should keep in mind that (apart from the other uncertainties that come with such a reconstruction) the Roman weight standard is unlikely to have remained constant to such a precision over the centuries, and that the provinces often had somewhat inexact copies of the standard. The weight and subdivision of the pound in the Holy Roman Empire were reformed by Charlemagne, but in the Byzantine Empire it remained essentially the same. Since Byzantine coins circulated up to Scandinavia, the old Roman standard continued to be influential through the Middle Ages.

Weight system of Salerno

The history of mediaeval medicine started roughly around the year 1000 with the school of medicine in Salerno, which combined elements of Latin, Greek, Arabic, and Jewish medicine. Galen and Dioscorides (who had used the Graeco-Roman weight system) were among the most important authorities, but also Arabic physicians, whose works were systematically translated into Latin.

According to De ponderibus et mensuris, a famous 13th-century text that exists in numerous variations and is often ascribed to Dino di Garbo, the system of weights used in Salerno was different from the systems used in Padua and Bologna. As can be seen from the table, it was also different from the Roman weight system used by Galenus and Dioscorides and from all modern apothecaries' systems: The ounce was divided into 9 drachms, rather than 8 drachms.

Centuries later, the region around Salerno was the only exception to the rule that (except for skipping units that had regionally fallen out of use) the apothecaries' ounce was subdivided down to the scruple in exactly the same way as in the Roman system: It divided the ounce into 10 drachms.

Romance countries

While there will naturally have been some changes throughout the centuries, this section only tries to give a general overview of the situation that was recorded in detail in numerous 19th-century merchants' handbooks.

Iberian Peninsula

On the Iberian Peninsula, apothecaries' weights in the 19th century were relatively uniform, with 24 grains per scruple (576 grains per ounce), the standard in Romance countries. The weight of an apothecaries' pound was 345.1 g in Spain and 344.2 g in Portugal. As in Italy, some of the additional subdivisions of the Roman system, such as the obolo, were still in use there. It was standard to use the marco, defined as 8 ounces, instead of the pound.

France

In 18th century France, there was a national weight standard, the marc de Paris of 8 ounces. The civil pound of 16 ounces was equivalent to 2 marks, and it was also used as the apothecaries' pound. With 30.6 g, the ounces were considerably heavier than other apothecaries ounces in Romance countries, but otherwise, the French system was not remarkable. Its history and connections to the English and Flemish standards are discussed below under Weight standards named after Troyes.

Italy

Due in part to the political conditions in what would become a united Kingdom of Italy only in 1861, the variation of apothecaries' systems and standard weights in this region was enormous. (For background information, see History of Italy during foreign domination and the unification.) The libbra (pound) generally consisted of the standard twelve ounces, however.

The civil weight systems were generally very similar to the apothecaries' system, and since the libbra (or the libbra sottile, where different systems were in use for light and heavy goods) generally had a suitable weight for an apothecaries' pound it was often used for this purpose. Extreme cases were Rome and Genoa, where the same system was used for everything, including medicine. On the other hand, there were relatively large differences even between two cities in the same state. E.g. Bologna (in the Papal States) had an apothecaries pound that was less than the local civil pound, and 4% lighter than the pound used in Rome.

The weight of an apothecaries' pound ranged generally between 300 g and 320 g, slightly less than that of a pound in the Roman Empire. An important exception to this rule is that the Kingdom of Lombardy–Venetia was under the rule of the Habsburg monarchy 1814–1859 and therefore had the extremely large Habsburg apothecaries' pound of 420 g. (See below under Habsburg standard.) E.g. in the large city of Milan the apothecaries' system based on a pound of 326.8 g was officially replaced by the metric system as early as 1803, because Milan was part of the Napoleonic Italian Republic. Since the successor of this little state, the Napoleonic Kingdom of Italy, fell to Habsburg in 1814 (at a time when even in France the système usuel had been introduced because the metric system was not accepted by the population), an apothecaries' system was officially introduced again, but now based on the Habsburg apothecaries' pound, which weighed almost 30% more.

The apothecaries' pound in Venice had exactly the same subdivisions as those in the non-Romance countries, but its total weight of 301 g was at the bottom of the range. During the Habsburg reign of 1814–1859 an exception was made for Venice; as a result, the extreme weights of 301 g and 420 g coexisted within one state and in immediate proximity. The Venice standard was also used elsewhere, for example in Udine. In Dubrovnik (called "Ragusa" until 1909) its use was partially continued for a long time in spite of the official Habsburg weight reform.

The measure and weight systems for the large mainland part of the Kingdom of the Two Sicilies were unified in 1840. The area consisted of the southern half of the Italian Peninsula and included Naples and Salerno. The subdivision of apothecaries' weight in the unified system was essentially the same as that for gold, silver, coins, and silk. It was the most excentric variant in that the ounce was divided in 10 drachms, rather than the usual 8. The scruple, like in Venice but unlike in the rest of the Romance region, was divided into 20 grains. The existence of a unit called aureo, the equivalent of 1+1⁄2 dramme, is interesting because 6 aurei were 9 dramme. In the original Salerno weight system an ounce was divided into 9 drachms, and so an aureo would have been 1⁄6 of an ounce.

Troyes, Nuremberg, and Habsburg

Weight standards named after Troyes

As early as 1147 in Troyes in Champagne (in the Middle Ages an important trading town) a unit of weight called marc de Troyes was used.

The national French standard until 1799 was based on a famous artifact called the Pile de Charlemagne, which probably dates back to the second half of the 15th century. It is an elaborate set of nesting weight pieces, with a total metric weight of 12.238 kg. The set is now shown in the Musée des Arts et Métiers in Paris. The total nominal value of the set is 50 marcs de Troyes or marcs de Paris, a mark being 8 ounces. The ounce poids de marc had therefore a metric equivalent of 30.59 g. The poids de marc was used as a national French standard for trading, for gold, silver, and jewels, and for weighing medicine. It was also used in international communications between scientists. In the time before the French Revolution, the civil pound also played the role of the apothecaries' pound in the French apothecaries' system, which otherwise remained a standard system of the Romance (24 grains per scruple) type.

In Bruges, Amsterdam, Antwerp and other Flemish cities, a "troy" unit ("trooisch pond") was also in use as a standard for valuable materials and medicine. As in France, the way in which the Flemish troy ounce was subdivided depended on what was weighed. Unlike the French, the Flemish apothecaries divided the scruple into 20 grains. The Flemish troy pound became the standard for the gold and apothecaries' system in the United Kingdom of the Netherlands; it was also used in this way in Lübeck. (The London troy pound was referred to as the 'trooisch pond', after metrification.)

The Dutch troy mark consisted of 8 Flemish troy ounces, with each ounce of 20 engels, and each engel divided into 32 assen. The Amsterdam Pound of two marks, used in commerce, weighed 10,280 assen, while the Amsterdam Troy pound weighed 10,240 assen, i.e. exactly two troy marks.

In 1414, six years before the Treaty of Troyes, a statute of Henry V of England gave directions to the goldsmiths in terms of the troy pound. (In 1304 it had apparently not yet been introduced, since it did not appear in the statute of weights and measures.) There is evidence from the 15th century that the troy pound was used for weighing metals and spices. After the abolishment of the Tower pound in 1527 by Henry VIII, the troy pound was the official basis for English coin weights. The British apothecaries' system was based on the troy pound until metrication, and it survived in the United States and Australia well into the 20th century.

Since the modern (English, American and Imperial) troy ounces are roughly 1.5% heavier than the late Paris ounce, the exact historical relations between the original marc de Troyes, the French poids de marc, the Flemish trooisch pond and the English troy pound are unclear. It is known, however, that the numerical relation between the English and French troy ounces was exactly 64:63 in the 14th century.

Nuremberg standard

In the Middle Ages the Imperial Free City of Nuremberg, an important trading place in the south of Germany, produced large amounts of nesting weight pieces to various European standards. In the 1540s, the first pharmacopoeia in the modern sense was also printed there. In 1555, a weight standard for the apothecaries' pound of 12 ounces was set in Nuremberg. Under the name Nuremberg pharmaceutical weight (German: Nürnberger Medizinalgewicht) it would become the standard for most of the north-east of Europe. However, some cities kept local copies of the standard.

As of 1800 all German states and cities except Lübeck (which had the Dutch troy standard) followed the Nuremberg standard. It was also the standard for Denmark, Norway, the Russian Empire, and most cantons of Switzerland. Poland and Sweden had their own variants of the standard, which differed from each other by 0.6%.

In 1811, Bavaria legally defined the apothecaries' pound as 360.00 g (an ounce of 30.00 g). In 1815, Nuremberg lost its status as a free city and became part of Bavaria. From now on the Nuremberg apothecaries' pound was no longer the official apothecaries' pound in Nuremberg; but the difference was only 0.6%. In 1836 the Greek apothecaries' pound was officially defined by this standard, four years after Otto, the son of the king of Bavaria, became the first king of Greece. But only few German states followed the example of Bavaria, and with a long delay. The apothecaries' pound of 360 g was also adopted in Lübeck, where it was official as of 1861.

Austria and the states of the Habsburg monarchy officially had a different standard since 1761, and Prussia, followed by its neighbours Anhalt, Lippe and Mecklenburg, would diverge in the opposite direction with a reform in 1816. But in both cases apothecaries continued to use the Nuremberg standard unofficially for a long time after it became illegal.

In Russia the apothecaries' system survived well into the 20th century. The Soviet Union officially abolished it only in January 1927.

Habsburg standard

Empress Maria Theresia of Austria reformed the measures and weights of the Habsburg monarchy in 1761. The weight of an apothecaries' pound of 12 ounces was increased to a value that was later (after the kilogramme was defined) found to be 420.009 g; this was called the libra medicinalis major. It was defined as 3⁄4 of the unusually heavy Habsburg civil pound (defined as 6⁄5 of the civil pound of Cologne) and corresponded to a record ounce weight of 35 g.

Before the reform, in the north of the empire, the Nuremberg standard had been in effect, and in Italy, the local standards had been even lighter. It is not surprising that an increase of 17% and more met with some inertia. The 1770 edition of the pharmacopoeia Dispensatorium Austriaco-Viennense still used the Nuremberg standard libra medicinalis minor, indicating that even in the Austrian capital Vienna it took some time for the reform to become effective. In 1774, the Pharmacopoea Austriaco-provincialis used the new standard, and in 1783 all old apothecaries' weight pieces that were still in use were directed to be destroyed.

Venice was not part of these reforms and kept its standard of approximately 25 g per ounce.

When Austria started producing scales and weight pieces to the new standard with an excellent quality/price ratio, these were occasionally used by German apothecaries as well.

Metrication

Early metrication

At the time of the Industrial Revolution, the fact that each state had its own system of weights and measures became increasingly problematic. Serious work on a "scientific" system was started in France under Louis XVI, and completed in 1799 (after the French Revolution) with its implementation. The French population, however, was initially unhappy with the new system. In 1812, Napoleon I reintroduced some of the old measurements, but in a modified form that was defined with respect to the metric system. This système usuel was finally abolished in 1837 and became illegal in 1840.

Due to the large expansion of the First French Empire under Napoleon I, French metrication also affected what would be (parts of) France's neighbour countries after the Congress of Vienna.

The Netherlands were partially metricated when they were French, in the years 1810–1813. With full metrication, effective January 1821, the Netherlands reformed the trooisch pond. The apothecaries' new pound was 375.00 g. Apart from rounding issues concerning the subdivisions, this corresponded exactly to the French système usuel. (The reform was not followed in the north German city of Lübeck, which continued to use the trooisch pond.) In Belgium, apothecaries' weight was metricated effective 1856.

From 1803 to 1815, all German regions west of the River Rhine were French, organised in the départements Roer, Sarre, Rhin-et-Moselle, and Mont-Tonnerre. As a result of the Congress of Vienna these became part of various German states. A large part of the Palatinate fell to Bavaria, but having the metric system it was excepted from the Bavarian reform of weights and measures.

Prussia's path to metrication

In Prussia, a reform in 1816 defined the Prussian civil pound in terms of the Prussian foot and distilled water. It also redefined the apothecaries' pound as 12 ounces, i.e. 3⁄4 of the civil pound: 350.78 g. This reform was not popular with apothecaries, because it broke the uniformity of the apothecaries' pound in Germany at a time when a German national state was beginning to form. It seems that many apothecaries did not follow this reduction by 2%.

Another reform in 1856 increased the civil pound from 467.711 g to 500.000 g (the German civil pound defined by the Zollverein), as a first step towards metrication. As a consequence the official apothecaries' pound was now 375.000 g, i.e. it was increased by 7%, and it was now very close to the troy standards. §4 of the law that introduced this reform said: "Further, a pharmaceutical weight deviating from the civil weight does not take place." But this paragraph was suspended until further notice.

The abolishment of the apothecaries' system meant that doctors' prescriptions had to use the current standards of measurement: grammes and kilograms. This was considered unfeasible by many, and the state received numerous protests and asked for expert advice. Nevertheless, by 1868 §4 of the earlier reform was finally put into force.

Metrication in countries using the troy and avoirdupois systems

Britain was initially involved in the development of the metric system, and the US was among the 17 initial signatories of the Metre Convention in 1875. Yet in spite of enthusiastic support for the new system by intellectuals such as Charles Dickens, these two countries were particularly slow to implement it.

In the US, the metric system replaced the apothecaries' system in the United States Pharmacopeia of 1971.

In the UK, metric drug measurements were required for dealings in drugs from January 1, 1971.