B vitamins
Group of vitamins
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Dietary supplements containing all eight are referred to as a vitamin B complex. Individual B vitamins are referred to by B-number or by chemical name, such as B1 for thiamine, B2 for riboflavin, and B3 for niacin, while some are more commonly recognized by name than by number, such as pantothenic acid (B5), biotin (B7), and folate (B9). B vitamins are present in protein-rich foods, such as fish, poultry, meat, dairy products, and eggs; they are also found in leafy green vegetables, beans, and peas. Fortified foods, such as breakfast cereals, baked products, and infant formulas, may contain B vitamins.
Each B vitamin is either a cofactor (generally a coenzyme) for key metabolic processes or is a precursor needed to make one.
List of B vitamins
Note: Other substances once thought to be vitamins were given B-numbers, but were disqualified once discovered to be either manufactured by the body or not essential for life. See § Related compounds for numbers 4, 8, 10, 11, and others.
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Molecular functions
To the right, a diagram of some of the major B vitamins (2, 3, 5, 9, and 12) are shown as precursors for certain essential biochemical reactants (FAD, NAD+, coenzyme A, tetrahydrofolate, and heme B respectively). The structural similarities between them are highlighted, which illustrates the precursor nature of many B vitamins while also showing the functionality of the end product used by essential reactions to support human, animal, or cellular life.
FAD, NAD+, and coenzyme A are all essential for the catabolic release of free energy (dG) to power the activity of the cell and more complex life forms. See the article on Catabolism for more details on how these three essential biochemical reactants help support life.
Tetrahydrofolate is a necessary co-reactant for synthesizing some amino acids, such as glycine. Heme B is the porphyrin derivative macrocycle molecule that holds the iron atom in place in hemoglobin, allowing for the transportation of oxygen through blood.
Deficiencies
Several named vitamin deficiency diseases may result from the lack of sufficient B vitamins. Deficiencies of other B vitamins result in symptoms that are not part of a named deficiency disease.
Side effects
Because water-soluble B vitamins are eliminated in the urine, taking large doses of most B vitamins usually only produces transient side effects (with the only exception being pyridoxine). General side effects may include restlessness, nausea, and insomnia. These side effects are almost always caused by dietary supplements and not food.
Discovery
Related compounds
Many of the following substances have been referred to as vitamins as they were once believed to be vitamins. They are no longer considered as such, and the numbers that were assigned to them now form the "gaps" in the true series of B-complex vitamins described above (for example, there is no vitamin B4). Some of them, though not essential to humans, are essential in the diets of other organisms; others have no known nutritional value and may even be toxic under certain conditions.
- Vitamin B4: can refer to the distinct chemicals choline, adenine, or carnitine.
- Choline is synthesized by the human body, but not sufficiently to maintain good health, and is now considered an essential dietary nutrient.
- Adenine is a nucleobase synthesized by the human body.
- Carnitine is an essential dietary nutrient for certain worms, but not for humans.
- Vitamin B8: adenosine monophosphate (AMP), also known as adenylic acid. Vitamin B8 may also refer to inositol.
- Vitamin B10: para-aminobenzoic acid (pABA or PABA), a chemical component of the folate molecule produced by plants and bacteria, and found in many foods. It is best known as a UV-blocking sunscreen applied to the skin, and is sometimes taken orally for certain medical conditions.
- Vitamin B11: pteroylheptaglutamic acid (PHGA; chick growth factor). Vitamin Bc-conjugate was also found to be identical to PHGA. Derivative of folate ("pteroylmonoglutamic acid" in this nomenclature).
- Vitamin B13: orotic acid.
- Vitamin B14: cell proliferant, anti-anemia, rat growth factor, and antitumor pterin phosphate, named by Earl R. Norris. Isolated from human urine at 0.33ppm (later in blood), but later abandoned by him as further evidence did not confirm this. He also claimed this was not xanthopterin.
- Vitamin B15: pangamic acid, also known as pangamate. Promoted in various forms as a dietary supplement and drug; considered unsafe and subject to seizure by the US Food and Drug Administration.
- Vitamin B16: dimethylglycine (DMG) is synthesized by the human body from choline.
- Vitamin B17: pseudoscientific name for the poisonous compound amygdalin, also known as "laetrile" or by the equally pseudoscientific name "nitrilosides" despite the fact that it is a single compound. Amygdalin can be found in various plants, but is most commonly extracted from apricot pits and other similar fruit kernels. Amygdalin is hydrolyzed by various intestinal enzymes to form, among other things, hydrogen cyanide, which is toxic to human beings when exposed to a high enough dosage. Some proponents claim that amygdalin is effective in cancer treatment and prevention, despite its toxicity and a lack of scientific evidence.
- Vitamin B20: L-carnitine.
- Vitamin Bf: carnitine.
- Vitamin Bm: myo-inositol, also called "mouse antialopaecia factor".
- Vitamin Bp: "antiperosis factor", which prevents perosis, a leg disorder, in chicks; can be replaced by choline and manganese salts.
- Vitamin BT: carnitine.
- Vitamin Bv: a type of B6 other than pyridoxine.
- Vitamin BW: a type of biotin other than d-biotin.
- Vitamin Bx: an alternative name for both pABA (see vitamin B10) and pantothenic acid.