Lably
Skip to content

Fenclonine

Chemical compound

  • 1 min read
  • 1 chapters

Related on Lably

Through Enzyme, Biosynthesis and Mental disorder

LabLife ProcessesLabFrom Tasting to DigestingLab · Class 11–12Biomolecules of LifeLab · Class 11Biomolecules — Animated Chapter Film

It has been used experimentally to treat carcinoid syndrome, but the side effects, mostly hypersensitivity reactions and psychiatric disturbances, have prevented development for this use.

The effects of serotonin depletion from fenclonine are so drastic that serotonin cannot even be detected immunohistochemically within the first day after administration of a control dose. TPH activity can be detected neither in cell bodies or nerve terminals. After one week 10% of control values (the baseline extrapolated for the study) had replenished in the raphe nucleus, and after two weeks from initial treatment as much was again detected in the hypothalamus region. Aromatic L-amino acid decarboxylase (AADC) levels were at no time affected.

It is used in scientific research in humans and animals to investigate the effects of serotonin depletion.

More in Neuroscience

StriatumNucleus in the basal ganglia of the brainBrain-derived neurotrophic factorProtein found in humansOrbitofrontal cortexRegion of the prefrontal cortex of the brainVentral tegmental areaGroup of neurons on the floor of the midbrainSlow-wave sleepPeriod of sleep in humans and other animalsVascular endothelial growth factorProtein involved in blood vessel growth