GcvB RNA
RNA family
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Through Transcription (biology)
Targets of GcvB
GcvB has been shown to regulate a large number of genes in E. coli and Salmonella species. GcvB was shown to bind to Oppa and DppA which transport oligopeptides and dipeptides respectively. It has been shown to also regulate gltL, argT, STM, livK, livJ, brnQ, sstT and cycA which are involved in uptake of a variety of amino acids. GcvB RNA also is involved in regulating a variety of genes involved in amino acid biosynthesis such as ilvC, gdhA, thrL and serA. GcvB RNA binds PhoPQ mRNA, which encodes a two-component system involved in magnesium homeostasis.
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Polymerisation
There is evidence that E. coli GcvB can form polymers. Native polyacrylamide gel electrophoresis was used to show a higher molecular weight band corresponding to a potential polymer. Transmission electron microscopy was then used to identify a filamentous structure for the polymer. However, the authors suggest that these long filaments are unlikely to be physiologically relevant. It was shown that a construct containing only the first 61 nucleotides including the first stem-loop was sufficient for polymerisation. Similar results were recently shown for the DsrA RNA. The physiological relevance of polymerisation is not known.
Species distribution
The GcvB RNA is found in a range of bacteria including: