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Through Human, Hair and Ethnicity

Discrimination based on hair also exists. Blonde women tend to be falsely stereotyped as unintelligent; redheads face vilification; and people with gray or no hair face professional discrimination.

Genetics and biochemistry of hair color

The full genetic basis of hair color is complex and not fully understood. Regulatory DNA is believed to be closely involved in pigmentation in humans in general, and a 2011 study by Branicki et al. identified 13 DNA variations across 11 different genes that could be used to predict hair color.

Two types of pigment give hair its color, black-brown eumelanin and reddish-brown/reddish-yellow pheomelanin, synthesized by melanocytes. Inside the melanocytes, tyrosine is converted into L-DOPA and then L-dopaquinone, which in turn is formed into pheomelanin or eumelanin.

Different hair color phenotypes arise primarily as a result of varying ratios of these two pigments in the human population, although Europeans show the greatest range in pigmentation overall. In addition, other genetic and environmental factors can affect hair color in humans; for instance, mutations in the melanocortin 1 receptor (MC1R) gene can lead to red or auburn hair, and exposure to ultraviolet radiation can damage hair and alter its pigmentation. Ultraviolet radiation (UV radiation) triggers greater synthesis of several compounds, including pro-opiomelanocortin (POMC), α-MSH, and ACTH, the result being increased eumelanin production. UV radiation most commonly comes from the sun, and thus populations from places closer to the equator tend to have darker hair, because eumelanin is generally more photoprotective than pheomelanin.

Pheomelanin colors hair orange and red. Eumelanin, which has two subtypes of black or brown, determines the darkness of the hair color; more black eumelanin leads to blacker hair and more brown eumelanin to browner hair. All human hair has some amount of both pigments. Over 95% of melanin content in black and brown hair is eumelanin. Pheomelanin is generally found in elevated concentrations in blond and red hair, representing about one-third of total melanin content. If there is no black eumelanin, the result is strawberry blond. Blond hair results from small amounts of brown eumelanin with no black eumelanin.

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