Perisinusoidal space
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Related on Lably
This space may be obliterated in liver disease, leading to decreased uptake by hepatocytes of nutrients and wastes such as bilirubin.
The Space of Disse is named for the German anatomist Joseph Disse (1852–1912).
Pathophysiology
Fibrosis
Liver injury from a number of causes can activate the hepatic stellate cells into transdifferentiated and prolific myofibroblasts. The myofibroblasts synthesize and secrete components of the extracellular matrix including collagen into the perisinusoidal space. This in turn promotes the development of fibrosis, and continuing fibrosis is thought to be responsible for the development of cirrhosis, and liver cancer.
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