Purine analogue
- 1 min read
- 2 chapters
Related on Lably
Through Autoimmunity
Examples
- Nucleobase analogues
- Thiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic leukemias.
- Azathioprine is the main immunosuppressive cytotoxic substance. A prodrug, it is widely used in transplantation to control rejection reactions. It is nonenzymatically cleaved to mercaptopurine, a purine analogue that inhibits DNA synthesis. By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both cell immunity and humoral immunity. It also successfully suppresses autoimmunity.
- Mercaptopurine
- Thioguanine
- Thiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic leukemias.
- Nucleoside analogues
- Clofarabine
- Pentostatin and cladribine are adenosine analogs that are used primarily to treat hairy cell leukemia.
- Nucleotide analogues
- Fludarabine inhibits multiple DNA polymerases, DNA primase, and DNA ligase I, and is S phase-specific (since these enzymes are highly active during DNA replication).
Sign in to keep reading
One more chapter is free with a Lably account.
Medical uses
Purine antimetabolites are commonly used to treat cancer by interfering with DNA replication.
More in Health
Food and Drug AdministrationFederal agency of the United States Department of Health and Human ServicesCenters for Disease Control and PreventionUnited States government public health agencyNauseaMedical symptom or conditionSeizurePeriod of symptoms due to excessive or synchronous neuronal brain activityVomitingExpulsion of stomach contents via the mouth or noseIntravenous therapyMedication administered into a vein